ข้อมูลจำเพาะที่สำคัญ/ คุณสมบัติพิเศษ:
Pentobarbital, a barbiturate, stelnat vatten used for the treatment of short term insomnia. It belongs to a group of medicines called viktig nervous system (CNS) depressants that induce drowsiness knipa relieve tension or nervousness.
pentobarbital will decrease the level or effect of quinine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
pentobarbital will decrease the level or effect of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Bildskärm. Strong or moderate CYP3A4 inducers may increase rate of diazepam elimination; therefore, efficacy of diazepam may vädja decreased.
pentobarbital will decrease the level or effect of midazolam ort affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Bildskärm.
However, the application of these data to other barbiturates appears valid knipa warrants serial blood level determinations of the relevant drugs when there are multiple therapies.
pentobarbital will decrease the level or effect of fosaprepitant samhälle affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Datorskärm.
pentobarbital will decrease the level or effect of maraviroc by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Bildskärm.
Pediatric neurotoxicity: Published animal studies demonstrate that the förvaltning of anesthetic knipa sedation drugs that modul NMDA receptors knipa/or potentiate GABA activity increase neuronal apoptosis in the developing brain and result in long-term cognitive deficits when used for longer than 3 hours. The clinical significance of these findings fruset vatten not clear. However, based on the available Värden, the window of vulnerability to these changes fruset vatten believed to correlate with exposures in the third trimester of gestation through the first several months of life, but may extend out to approximately three years of age in humans (see “Precautions-Pregnancy knipa Pediatric Use” and “Animal Pharmacology and/or Toxicology”). Some published studies in children suggest that similar deficits may occur after repeated or prolonged exposures to anesthetic agents early in life knipa may result in adverse cognitive or behavioral effects.
Monitor Closely (1)pentobarbital will decrease the level or effect of benzhydrocodone/acetaminophen ort affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Datorskärm Closely. Caution when discontinuing CYP3A4 inducers that are coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone may increase knipa can result in potentially fatal respiratory depression.
Animal Datorer inte. Phenobarbital sodium is carcinogenic in mice and Köp Nembutal Pentobarbitalnatrium online rats after lifetime administration. In mice, it produced benign and malignant liver cell tumors. In rats, benign liver cell tumors were observed very late in life.
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Corticosteroids: Barbiturates appear to enhance the metabolism of exogenous corticosteroids probably through the induction of hepatic microsomal enzymes. Patients stabilized on corticosteroid therapy may require dosage adjustments if barbiturates are added to or withdrawn from their dosage regimen.
pentobarbital will decrease the level or effect of etravirine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.